Benjamin Henwood, PhD, and Deborah Padgett, PhD, network co-leads for the Grand Challenge to End Homelessness, have written a chapter in the newly published book, Homelessness Prevention and Intervention in Social Work: Policies, Programs, and Practices. The chapter, “Homelessness in Los Angeles and New York City: A Tale of Two Cities” explores the U.S. response to homelessness over the years. Drs. Henwood and Padgett describe how New York City and Los Angeles have approached homelessness in vastly different ways and examine how addressing local variation is critical to future efforts to end homelessness.